Nature Communications (Jan 2017)

A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens

  • Chen Li,
  • Yusuke Sako,
  • Akihiro Imai,
  • Tomoaki Nishiyama,
  • Kari Thompson,
  • Minoru Kubo,
  • Yuji Hiwatashi,
  • Yukiko Kabeya,
  • Dale Karlson,
  • Shu-Hsing Wu,
  • Masaki Ishikawa,
  • Takashi Murata,
  • Philip N. Benfey,
  • Yoshikatsu Sato,
  • Yosuke Tamada,
  • Mitsuyasu Hasebe

DOI
https://doi.org/10.1038/ncomms14242
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Land plants and metazoans are both able to reprogram differentiated cells to stem cells under certain circumstances. Here the authors show that the moss CSP1 protein, which shares conserved domains with the mammalian pluripotent stem cell factor Lin28, promotes reprogramming of leaf cells to apical stem cells.