Genetic kidney disease has a higher likelihood and cost of inpatient admissions compared to other aetiologies

P. Marcin Sowa; Andrew J. Mallett; Luke B. Connelly

Genetics in Medicine Open (Jan 2024)

Genetic kidney disease has a higher likelihood and cost of inpatient admissions compared to other aetiologies

P. Marcin Sowa,
Andrew J. Mallett,
Luke B. Connelly

Affiliations

P. Marcin Sowa: Centre for the Business and Economics of Health, The University of Queensland, St Lucia, Queensland, Australia; NHMRC Chronic Kidney Disease Centre of Research Excellence, The University of Queensland, Herston, Queensland, Australia; P. Marcin Sowa, The University of Queensland, Level 5, Sir Llew Edwards Building (#14), St Lucia, Queensland 4072, Australia.
Andrew J. Mallett: NHMRC Chronic Kidney Disease Centre of Research Excellence, The University of Queensland, Herston, Queensland, Australia; Institute for Molecular Bioscience and Faculty of Medicine, The University of Queensland, Brisbane, Australia; Department of Renal Medicine, Townsville University Hospital, Townsville, Australia; College of Medicine & Dentistry, James Cook University, Townsville, Australia; KidGen Collaborative, Australian Genomics Health Alliance, Parkville, Australia; Correspondence and requests for materials should be addressed to Andrew J. Mallett, Level 2, Townsville University Hospital, Angus Smith Drive, Douglas, 4814, Queensland, Australia.
Luke B. Connelly: Centre for the Business and Economics of Health, The University of Queensland, St Lucia, Queensland, Australia; NHMRC Chronic Kidney Disease Centre of Research Excellence, The University of Queensland, Herston, Queensland, Australia; Department of Sociology and Business Law, The University of Bologna, Bologna, Italy

Journal volume & issue: Vol. 2
p. 101876

Abstract

Read online

Purpose: There is increasing recognition of monogenic aetiologies for kidney disease. We sought to identify whether genetic kidney disease (GKD) has distinct hospitalization patterns compared to other forms of chronic kidney disease (CKD). Methods: Health service utilization analysis was undertaken in a CKD cohort study across public hospital services in Queensland, Australia. CKD due to clinically coded potential monogenic causes was compared to all other causes in terms of annual frequency, cost, and type of hospital admission. Results: We analyzed 7 years of hospital admissions data (809,188 admissions) among 29,046 patients. Compared to non-genetic CKD, GKD was associated with a higher likelihood and cost of admissions. GKD had consistently more admissions (mean excess annual number of admissions increasing from 5.2 in year 1 to 13.4 in year 7) and more costly admissions (mean excess annual cost increasing from $5,265 in year 1 to $12,993 in year 7). This gap in hospitalization likelihood and cost increased over time for both surgical and medical admission episodes, but not for all (immunological, cancer) causes of admissions. Conclusion: Understanding the nature and extent of differences in healthcare needs between GKD and other CKD will enable better secondary prevention and inform resource allocation decisions to reduce healthcare system pressures attributable to knowable causes.

Published in Genetics in Medicine Open

ISSN: 2949-7744 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Biology (General): Genetics; Medicine
Website: https://www.sciencedirect.com/journal/genetics-in-medicine-open

About the journal

Abstract

Keywords