Direct deoxygenative borylation of carboxylic acids

Jianbin Li; Chia-Yu Huang; Mohamad Ataya; Rustam Z. Khaliullin; Chao-Jun Li

doi:10.1038/s41467-021-25229-8

Nature Communications (Aug 2021)

Direct deoxygenative borylation of carboxylic acids

Jianbin Li,
Chia-Yu Huang,
Mohamad Ataya,
Rustam Z. Khaliullin,
Chao-Jun Li

Affiliations

Jianbin Li: Department of Chemistry, McGill University
Chia-Yu Huang: Department of Chemistry, McGill University
Mohamad Ataya: Department of Chemistry, McGill University
Rustam Z. Khaliullin: Department of Chemistry, McGill University
Chao-Jun Li: Department of Chemistry, McGill University

DOI: https://doi.org/10.1038/s41467-021-25229-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Converting a carboxylic acid into a boronic acid, which makes a useful chemical handle from a feedstock chemical, currently relies on decarboxylation and requires metal catalysts and prior functionalization. Here the authors show a simplified procedure via deoxygenation, using diboron and free carboxylic acids.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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