RUDN Journal of Medicine (Sep 2011)

Matricsins 2, 7 and 9 in breast tumors. determination of posibile connection with the concentration of HER-2/neu

  • O M Kuznetsova,
  • Т Т Berezov,
  • N N Chernov,
  • A Y Nazarenko,
  • Yu V Kryuk,
  • I V Tereshkina,
  • N E Kushlinskii

Journal volume & issue
Vol. 0, no. 3
pp. 34 – 38

Abstract

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The comparative analysis of the quantity of matrix metalloproteinases (MMP) 2,7 and 9 in breast cancer is carried out; the concentration of sex hormones receptors and protein HER-2/neu are determined. Authentically high values MMP-2 and MMP-7 are found in a tumor tissue in contrast to the normal one. The elevated concentration of ММР-2 in a tumor is connected with receptor status (p < 0,05). The highest values of concentration ММР-7 and ММP- 9 are found at RE-, RP- and HER-2/neu + tumors, and also in the tumors with the size more than 4,0 cm.

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