Nature Communications (Mar 2018)

Reconstruction of complex single-cell trajectories using CellRouter

  • Edroaldo Lummertz da Rocha,
  • R. Grant Rowe,
  • Vanessa Lundin,
  • Mohan Malleshaiah,
  • Deepak Kumar Jha,
  • Carlos R. Rambo,
  • Hu Li,
  • Trista E. North,
  • James J. Collins,
  • George Q. Daley

DOI
https://doi.org/10.1038/s41467-018-03214-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Single cell analysis provides insight into cell states and transitions, but to interpret the data, improved algorithms are needed. Here, the authors present CellRouter as a method to analyse single-cell trajectories from RNA-sequencing data, and provide insight into erythroid, myeloid and lymphoid differentiation.