PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

Corina T. Madreiter-Sokolowski; Christiane Klec; Warisara Parichatikanond; Sarah Stryeck; Benjamin Gottschalk; Sergio Pulido; Rene Rost; Emrah Eroglu; Nicole A. Hofmann; Alexander I. Bondarenko; Tobias Madl; Markus Waldeck-Weiermair; Roland Malli; Wolfgang F. Graier

doi:10.1038/ncomms12897

Nature Communications (Sep 2016)

PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

Corina T. Madreiter-Sokolowski,
Christiane Klec,
Warisara Parichatikanond,
Sarah Stryeck,
Benjamin Gottschalk,
Sergio Pulido,
Rene Rost,
Emrah Eroglu,
Nicole A. Hofmann,
Alexander I. Bondarenko,
Tobias Madl,
Markus Waldeck-Weiermair,
Roland Malli,
Wolfgang F. Graier

Affiliations

Corina T. Madreiter-Sokolowski: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Christiane Klec: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Warisara Parichatikanond: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Sarah Stryeck: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Benjamin Gottschalk: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Sergio Pulido: Institute of Chemistry, University of Graz
Rene Rost: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Emrah Eroglu: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Nicole A. Hofmann: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Alexander I. Bondarenko: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Tobias Madl: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Markus Waldeck-Weiermair: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Roland Malli: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz
Wolfgang F. Graier: Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz

DOI: https://doi.org/10.1038/ncomms12897
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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MICU1 is a regulatory subunit of mitochondrial Ca2+ channels that shields mitochondria from Ca2+ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca2+ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca2+uptake activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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