Diabetes, Metabolic Syndrome and Obesity (Feb 2023)

Investigation of Hyperlipidemia Associated with Increased Levels of Oxidized Low-Density Lipoproteins and 8-Hydroxy-2´-Deoxyguanosine

  • Babakr A,
  • Mukhtar M,
  • Althubiti M,
  • Al-Amodi H,
  • Almaimani R,
  • Nour Eldin MM,
  • Elzubeir Abdalla M,
  • Nasif W

Journal volume & issue
Vol. Volume 16
pp. 447 – 455

Abstract

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Abdullatif Babakr,1 Mohamed Mukhtar,1 Mohamed Althubiti,1 Hiba Al-Amodi,1 Riyad Almaimani,1 Mohamed Mahmoud Nour Eldin,1 Mohamed Elzubeir Abdalla,1 Wesam Nasif1,2 1Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; 2Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, EgyptCorrespondence: Abdullatif Babakr, Department of Medical Biochemistry, Faculty of medicine, Umm Al-Qura University, Abdia, Makkah, Kingdom of Saudi Arabia, Tel +966-25270000/4322, Fax +96625270000/4319, Email [email protected]: Hyperlipidemia is a common risk factor for atherosclerosis, heart diseases, and other pathological conditions. The factors leading to the oxidation of native low-density lipoproteins remain of valuable importance for a better understanding of the mechanisms leading to these pathologies. The aim of the present study was to evaluate the association between lipid status and the levels of oxidized low-density lipoproteins and 8-hydroxy-2´-deoxyguanosine.Methods: One hundred and fourteen participants were enrolled. Lipid profile parameters were measured and used individually to categorize subjects into two groups of normal and hyperlipidemic cases according to the international reference ranges. Oxidized low-density lipoproteins and 8-hydroxy-2´-deoxyguanosine were then compared in normal and high lipid profile groups. The obtained results were then statistically analyzed.Results: 8-Hydroxy-2´-deoxyguanosine was found to be positively correlated with hypercholesterolemia, hypertriglyceridemia, and high levels of low-density lipoproteins (r = 0.53, 0.41, and 0.60), respectively (p< 0.001). A positive correlation was observed also between the levels of oxidized low-density lipoproteins and the same lipid profile parameters (r = 0.42, 0.31, and 0.45), respectively (p< 0.001).Conclusion: The present study suggests that disturbance in lipid profile may result in increased levels of oxidized low-density lipoproteins and oxidative stress in the study group; however, a larger sample is needed to confirm the present findings.Keywords: oxidized LDL, 8-OH-dG, dyslipidemia, DNA damage

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