Nature Communications (May 2021)
Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer
- Bernard Pereira,
- Christopher T. Chen,
- Lipika Goyal,
- Charlotte Walmsley,
- Christopher J. Pinto,
- Islam Baiev,
- Read Allen,
- Laura Henderson,
- Supriya Saha,
- Stephanie Reyes,
- Martin S. Taylor,
- Donna M. Fitzgerald,
- Maida Williams Broudo,
- Avinash Sahu,
- Xin Gao,
- Wendy Winckler,
- A. Rose Brannon,
- Jeffrey A. Engelman,
- Rebecca Leary,
- James R. Stone,
- Catarina D. Campbell,
- Dejan Juric
Affiliations
- Bernard Pereira
- Novartis Institutes for Biomedical Research
- Christopher T. Chen
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Lipika Goyal
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Charlotte Walmsley
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Christopher J. Pinto
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Islam Baiev
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Read Allen
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Laura Henderson
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Supriya Saha
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Stephanie Reyes
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Martin S. Taylor
- Department of Pathology, Massachusetts General Hospital
- Donna M. Fitzgerald
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Maida Williams Broudo
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Avinash Sahu
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Xin Gao
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- Wendy Winckler
- Novartis Institutes for Biomedical Research
- A. Rose Brannon
- Novartis Institutes for Biomedical Research
- Jeffrey A. Engelman
- Novartis Institutes for Biomedical Research
- Rebecca Leary
- Novartis Institutes for Biomedical Research
- James R. Stone
- Department of Pathology, Massachusetts General Hospital
- Catarina D. Campbell
- Novartis Institutes for Biomedical Research
- Dejan Juric
- Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-021-23394-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations than single tissue samples.
