Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10–what distinguishes the two?

Aya Ikeda; Yuzuru Imai; Yuzuru Imai; Nobutaka Hattori; Nobutaka Hattori; Nobutaka Hattori; Nobutaka Hattori; Nobutaka Hattori

doi:10.3389/fcell.2022.996061

Frontiers in Cell and Developmental Biology (Sep 2022)

Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10–what distinguishes the two?

Aya Ikeda,
Yuzuru Imai,
Yuzuru Imai,
Nobutaka Hattori,
Nobutaka Hattori,
Nobutaka Hattori,
Nobutaka Hattori,
Nobutaka Hattori

Affiliations

Aya Ikeda: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Yuzuru Imai: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Yuzuru Imai: Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan
Nobutaka Hattori: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Nobutaka Hattori: Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan
Nobutaka Hattori: Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, Tokyo, Japan
Nobutaka Hattori: Center for Genomic and Regenerative Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan
Nobutaka Hattori: Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan

DOI: https://doi.org/10.3389/fcell.2022.996061
Journal volume & issue: Vol. 10

Abstract

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Coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) are mitochondrial proteins that are thought to be genes which duplicated during evolution and are the causative genes for Parkinson’s disease and amyotrophic lateral sclerosis/frontotemporal lobe dementia, respectively. CHCHD2 forms a heterodimer with CHCHD10 and a homodimer with itself, both of which work together within the mitochondria. Various pathogenic and disease-risk variants have been identified; however, how these mutations cause neurodegeneration in specific diseases remains a mystery. This review focuses on important new findings published since 2019 and discusses avenues to solve this mystery.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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