Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies

• Rohan Khera,
• Yuan Lu,
• Harlan M Krumholz,
• Martijn J Schuemie,
• Ruijun Chen,
• George Hripcsak,
• Marc A Suchard,
• Patrick B Ryan,
• Anna Ostropolets

Affiliations

Rohan Khera

1Department of Internal Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, USA

Yuan Lu

Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, and Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Harlan M Krumholz

Harold H Hines Junior professor of medicine and epidemiology and public health

Martijn J Schuemie

3Department of Epidemiology Janssen Research & Development, Titusville, New Jersey, USA

Ruijun Chen

Biomedical Informatics, Columbia University Irving Medical Center, New York City, New York, USA

George Hripcsak

Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York, USA

Marc A Suchard

Department of Biostatistics, Fielding School of Publich Health, University of California, Los Angeles, California, USA

Patrick B Ryan

vice president and assistant professor

Anna Ostropolets

Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York, USA