Communications Biology (Feb 2021)

Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation

  • Keisuke Takeda,
  • Aoi Uda,
  • Mikihiro Mitsubori,
  • Shun Nagashima,
  • Hiroko Iwasaki,
  • Naoki Ito,
  • Isshin Shiiba,
  • Satoshi Ishido,
  • Masaaki Matsuoka,
  • Ryoko Inatome,
  • Shigeru Yanagi

DOI
https://doi.org/10.1038/s42003-021-01720-2
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Takeda et al. investigate the role of mitochondrial ubiquitin ligase (MITOL) in Alzheimer’s disease progression. They demonstrate that MITOL has a direct effect on mitochondrial dynamics and functioning and its ablation can enhance the seeding effect of Aβ-plaques, leading to cognitive decline in the transgenic mice model of Alzheimer’s disease.