A RNA producing DNA hydrogel as a platform for a high performance RNA interference system

Jaejung Song; Minhyuk Lee; Taeyoung Kim; Jeongkyeong Na; Yebin Jung; Gyoo Yeol Jung; Sungjee Kim; Nokyoung Park

doi:10.1038/s41467-018-06864-0

Nature Communications (Oct 2018)

A RNA producing DNA hydrogel as a platform for a high performance RNA interference system

Jaejung Song,
Minhyuk Lee,
Taeyoung Kim,
Jeongkyeong Na,
Yebin Jung,
Gyoo Yeol Jung,
Sungjee Kim,
Nokyoung Park

Affiliations

Jaejung Song: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH)
Minhyuk Lee: Department of Chemistry, Myongji University
Taeyoung Kim: Department of Chemistry, Myongji University
Jeongkyeong Na: Department of Chemical Engineering, POSTECH
Yebin Jung: Department of Chemistry, POSTECH
Gyoo Yeol Jung: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH)
Sungjee Kim: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH)
Nokyoung Park: Department of Chemistry, Myongji University

DOI: https://doi.org/10.1038/s41467-018-06864-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Interfering RNA have a range of therapeutic and research based applications, issues with delivery have made systems that make siRNA in situ of interest. Here, the author report on the creation of a DNA hydrogel with improved stability and transcription efficiency over plasmid DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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