<i>Helicobacter pylori</i> Eradication Does Not Adversely Affect the Clinical Course of Gastric Cancer: A Multicenter Study on Screening Endoscopic Examination in Japan

So Takahashi; Kenta Watanabe; Sho Fukuda; Tatsuki Yoshida; Takahiro Dohmen; Junichi Fujiwara; Mari Matsuyama; Shusei Fujimori; Masato Funaoka; Kodai Shirayama; Yohei Horikawa; Saki Fushimi; Shu Uchikoshi; Kengo Onochi; Ryo Okubo; Takao Hoshino; Toru Horii; Taira Kuramitsu; Kotaro Sakaki; Toru Ishii; Taiga Komatsu; Yuko Yoshida; Kenji Shirane; Tsuyoshi Ono; Yosuke Shimodaira; Tamotsu Matsuhashi; Katsunori Iijima

doi:10.3390/cancers16040733

Cancers (Feb 2024)

<i>Helicobacter pylori</i> Eradication Does Not Adversely Affect the Clinical Course of Gastric Cancer: A Multicenter Study on Screening Endoscopic Examination in Japan

So Takahashi,
Kenta Watanabe,
Sho Fukuda,
Tatsuki Yoshida,
Takahiro Dohmen,
Junichi Fujiwara,
Mari Matsuyama,
Shusei Fujimori,
Masato Funaoka,
Kodai Shirayama,
Yohei Horikawa,
Saki Fushimi,
Shu Uchikoshi,
Kengo Onochi,
Ryo Okubo,
Takao Hoshino,
Toru Horii,
Taira Kuramitsu,
Kotaro Sakaki,
Toru Ishii,
Taiga Komatsu,
Yuko Yoshida,
Kenji Shirane,
Tsuyoshi Ono,
Yosuke Shimodaira,
Tamotsu Matsuhashi,
Katsunori Iijima

Affiliations

So Takahashi: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Kenta Watanabe: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Sho Fukuda: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Tatsuki Yoshida: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Takahiro Dohmen: Department of Gastroenterology, Yuri Kumiai General Hospital, 38 Ienoushiro, Kawaguchi, Yurihonjo 015-8511, Akita, Japan
Junichi Fujiwara: Department of Gastroenterology, Yuri Kumiai General Hospital, 38 Ienoushiro, Kawaguchi, Yurihonjo 015-8511, Akita, Japan
Mari Matsuyama: Department of Gastroenterology, Yuri Kumiai General Hospital, 38 Ienoushiro, Kawaguchi, Yurihonjo 015-8511, Akita, Japan
Shusei Fujimori: Department of Gastroenterology, Yokote Municipal Hospital, 5-31 Negishi, Yokote 013-8602, Akita, Japan
Masato Funaoka: Department of Gastroenterology, Yokote Municipal Hospital, 5-31 Negishi, Yokote 013-8602, Akita, Japan
Kodai Shirayama: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Yohei Horikawa: Department of Gastroenterology, Hiraka General Hospital, 3-1 Yatsukuchi, Maego, Yokote 013-8610, Akita, Japan
Saki Fushimi: Department of Gastroenterology, Hiraka General Hospital, 3-1 Yatsukuchi, Maego, Yokote 013-8610, Akita, Japan
Shu Uchikoshi: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Kengo Onochi: Department of Gastroenterology, Omagari Kosei Medical Center, 8-65 Omagaritori, Daisen 014-0027, Akita, Japan
Ryo Okubo: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Takao Hoshino: Department of Gastroenterology, Akita Kosei Medical Center, 1-1-1 Nishibukuro, Iijima, Akita 011-0948, Akita, Japan
Toru Horii: Department of Gastroenterology, Akita Kosei Medical Center, 1-1-1 Nishibukuro, Iijima, Akita 011-0948, Akita, Japan
Taira Kuramitsu: Department of Gastroenterology, Akita Kosei Medical Center, 1-1-1 Nishibukuro, Iijima, Akita 011-0948, Akita, Japan
Kotaro Sakaki: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Toru Ishii: Department of Gastroenterology, Akita Red Cross Hospital, 222-1 Nawashirosawa, Kamikitatesaruta, Akita 010-1495, Akita, Japan
Taiga Komatsu: Department of Gastroenterology, Honjo-Daiichi Hospital, 110 Iwabuchishita, Yurihonjo 015-8567, Akita, Japan
Yuko Yoshida: Department of Gastroenterology, Honjo-Daiichi Hospital, 110 Iwabuchishita, Yurihonjo 015-8567, Akita, Japan
Kenji Shirane: Department of Gastroenterology, Shirane Hospital, 5-29 Kyokuhokusakae, Akita 010-0922, Akita, Japan
Tsuyoshi Ono: Department of Gastroenterology, Omori Municipal Hospital, 245-205 Sugouta, Omori, Yokote 013-0525, Akita, Japan
Yosuke Shimodaira: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Tamotsu Matsuhashi: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan
Katsunori Iijima: Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Akita, Japan

DOI: https://doi.org/10.3390/cancers16040733
Journal volume & issue: Vol. 16, no. 4
p. 733

Abstract

Read online

Background: Since gastric cancers (GCs) detected after Helicobacter pylori (HP) eradication present with different morphological characteristics from conventional HP-positive GCs, delayed detection of early-stage GCs may be observed. This study aimed to investigate the clinical impact of HP eradication on diagnosing GC during screening endoscopy. Methods: Eleven health checkup institutions in Japan participated in the present study. All GC cases newly diagnosed by screening endoscopy between January 2016 and December 2020 were included. After propensity score matching, multivariable regression analysis was performed to estimate the effect of HP eradication on deep tumor invasion among HP-eradicated and HP-positive GC cases. Results: A total of 231 patients with GCs (134 HP-eradicated and 97 HP-positive cases) were enrolled. After propensity score matching, there were 81 cases in each group. The distribution of the depth of tumor invasion (pT1a, pT1b1, pT1b2, and pT2) between the HP-eradicated group and HP-positive group was similar (p = 0.82). In the propensity analysis, with HP-positive as the reference value, HP eradication was not significantly associated with T1b–T4-GCs and T1b2–T4-GCs, with odds ratios (95% confidence intervals) of 1.16 (0.48–2.81) and 1.16 (0.42–3.19), respectively. Conclusions: HP eradication does not adversely affect the clinical course of GCs, supporting the recommendation of HP eradication in screening programs to reduce the total number of GC cases without delaying diagnosis.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

About the journal

Abstract

Keywords