Nature Communications (Apr 2018)

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

  • Yukinori Okada,
  • Yukihide Momozawa,
  • Saori Sakaue,
  • Masahiro Kanai,
  • Kazuyoshi Ishigaki,
  • Masato Akiyama,
  • Toshihiro Kishikawa,
  • Yasumichi Arai,
  • Takashi Sasaki,
  • Kenjiro Kosaki,
  • Makoto Suematsu,
  • Koichi Matsuda,
  • Kazuhiko Yamamoto,
  • Michiaki Kubo,
  • Nobuyoshi Hirose,
  • Yoichiro Kamatani

DOI
https://doi.org/10.1038/s41467-018-03274-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

Read online

Recent natural selection left signals in human genomes. Here, Okada et al. generate high-depth whole-genome sequence (WGS) data (25.9×) from 2,234 Japanese people of the BioBank Japan Project (BBJ), and identify signals of recent natural selection which overlap variants associated with human traits.