Nature Communications (Jan 2021)

A circadian clock regulates efflux by the blood-brain barrier in mice and human cells

  • Shirley L. Zhang,
  • Nicholas F. Lahens,
  • Zhifeng Yue,
  • Denice M. Arnold,
  • Peter P. Pakstis,
  • Jessica E. Schwarz,
  • Amita Sehgal

DOI
https://doi.org/10.1038/s41467-020-20795-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The blood-brain barrier is critical for neural function. Here, the authors show that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells.