Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations

Asha M. Mahajan, MD; Yuval Itan, PhD; Marina Cerrone, MD; James Horowitz, MD; Linda Borneman, MA; Larry Chinitz, MD; Lior Jankelson, MD, PhD

JACC: Case Reports (Feb 2021)

Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations

Asha M. Mahajan, MD,
Yuval Itan, PhD,
Marina Cerrone, MD,
James Horowitz, MD,
Linda Borneman, MA,
Larry Chinitz, MD,
Lior Jankelson, MD, PhD

Affiliations

Asha M. Mahajan, MD: Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA
Yuval Itan, PhD: Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA; The Charles Bronfman Institute for Personalized Medicine, Mount Sinai School of Medicine, New York, New York, USA
Marina Cerrone, MD: Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA
James Horowitz, MD: Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA
Linda Borneman, MA: Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA
Larry Chinitz, MD: Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA
Lior Jankelson, MD, PhD: Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA; Address for correspondence: Dr. Lior Jankelson, Heart Rhythm Center, Leon H. Charney Division of Cardiology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.

Journal volume & issue: Vol. 3, no. 2
pp. 242 – 246

Abstract

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Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogenesis in Bi-MVP patients. (Level of Difficulty: Intermediate.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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