Nature Communications (Aug 2019)

Interplay of protein corona and immune cells controls blood residency of liposomes

  • Francesca Giulimondi,
  • Luca Digiacomo,
  • Daniela Pozzi,
  • Sara Palchetti,
  • Elisabetta Vulpis,
  • Anna Laura Capriotti,
  • Riccardo Zenezini Chiozzi,
  • Aldo Laganà,
  • Heinz Amenitsch,
  • Laura Masuelli,
  • Giovanna Peruzzi,
  • Morteza Mahmoudi,
  • Isabella Screpanti,
  • Alessandra Zingoni,
  • Giulio Caracciolo

DOI
https://doi.org/10.1038/s41467-019-11642-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Protein corona formation is known to have significant effects upon nanomaterials application. Here, the authors investigate the creation of a protein coating on liposomes with the aim of improving liposome circulation time by avoiding leukocyte capture and demonstrated application in vitro and ex vivo.