A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)
Rosita Cappai,
Alessandra Fantasia,
Guido Crisponi,
Eugenio Garribba,
M. Amélia Santos,
Valeria Marina Nurchi
Affiliations
Rosita Cappai
Dipartimento di Scienze della Vita e dell’Ambiente, Università di Cagliari, 09042 Monserrato-Cagliari, Italy
Alessandra Fantasia
Dipartimento di Scienze della Vita e dell’Ambiente, Università di Cagliari, 09042 Monserrato-Cagliari, Italy
Guido Crisponi
Dipartimento di Scienze della Vita e dell’Ambiente, Università di Cagliari, 09042 Monserrato-Cagliari, Italy
Eugenio Garribba
Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Università di Sassari, Viale San Pietro, 07100 Sassari, Italy
M. Amélia Santos
Centro de Quimica Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
Valeria Marina Nurchi
Dipartimento di Scienze della Vita e dell’Ambiente, Università di Cagliari, 09042 Monserrato-Cagliari, Italy
The increasing biomedical interest in high-stability oxidovanadium(IV) complexes with hydroxypyridinone ligands leads us to investigate the complex formation equilibria of VIVO2+ ion with a tetradentate ligand, named KC21, which contains two 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) moieties, and with the simple bidentate ligand that constitutes the basic unit of KC21, for comparison, named L5. These equilibrium studies were conducted with joined potentiometric–spectrophotometric titrations, and the results were substantiated with EPR measurements at variable pH values. This multi-technique study gave evidence of the formation of an extremely stable 1:1 complex between KC21 and oxidovanadium(IV) at a physiological pH, which could find promising pharmacological applications.
