Nature Communications (May 2020)

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

  • Beth Lucas,
  • Andrea J. White,
  • Emilie J. Cosway,
  • Sonia M. Parnell,
  • Kieran D. James,
  • Nick D. Jones,
  • Izumi Ohigashi,
  • Yousuke Takahama,
  • William E. Jenkinson,
  • Graham Anderson

DOI
https://doi.org/10.1038/s41467-020-16041-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of mTEC for specific control of multiple lineages of invariant natural killer T cells.