Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

Junji Xing; Ao Zhang; Yong Du; Mingli Fang; Laurie J. Minze; Yong-Jun Liu; Xian Chang Li; Zhiqiang Zhang

doi:10.1038/s41467-021-23003-4

Nature Communications (May 2021)

Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells

Junji Xing,
Ao Zhang,
Yong Du,
Mingli Fang,
Laurie J. Minze,
Yong-Jun Liu,
Xian Chang Li,
Zhiqiang Zhang

Affiliations

Junji Xing: Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist
Ao Zhang: Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist
Yong Du: Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist
Mingli Fang: Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist
Laurie J. Minze: Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist
Yong-Jun Liu: Innovent Biologics Inc
Xian Chang Li: Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist
Zhiqiang Zhang: Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist

DOI: https://doi.org/10.1038/s41467-021-23003-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

Read online

Innate immune cells play critical roles patrolling for and detecting viral infection by expression of a range of nucleic acid sensors. Here the authors implicate PARP9 in the detection of viral RNA and the induction of the IFN pathway via PI3K/AKT3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal