Терапевтический архив (Dec 2008)
Effects of age-related androgen deficiency on clinicopsychological characteristics of patients with ischemic heart disease
Abstract
Aim. To study prevalence of androgen deficiency and its relations with clinicopsychological disorders in males with ischemic heart disease (IHD). Material and methods. A total of 87 males aged 31-60 years (58 with stable angina of effort FCII- III, 29 with progressive angina of effort) participated in the study. Clinical symptoms of androgen deficiency, severity of anxiety and depression, quality of life were characterized with scales AMS, HADS, D.M. Aronov and V.P. Zaitsev method (2002), respectively. Left ventricular myocardial mass (LVMM) was calculated according to R.Devereux and N. Reichek formula. Results. Symptoms of male sexual hormones deficiency were seen in 67.8% examinees. In the age groups 31-40, 41-50, 51-60 years androgenic deficiency was diagnosed in 50, 85.7 and 82.9% patients, respectively. A direct correlation was found between androgenic deficiency and total cholesterol (R = 0.38), prothrombin index (R = 0.39), LVMM index (R = 0.48), severity of depression (R = 0.71), anxiety (R = 0.5) and inverse correlation - between androgenic deficiency and quality of life (R = -0.69). Conclusion. Young and middle-aged patients with ischemic heart disease have symptoms of androgenic deficiency in 67.8% cases. This fact necessitates screening testing of such patients with AMS questionnaire. Male sex hormones deficiency is associated with high anxiety and depression, while quality of life is subnormal.
