PLoS ONE (Jan 2016)

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.

  • Maxwell Greene,
  • Yongjie Lai,
  • Kostandin Pajcini,
  • Will Bailis,
  • Warren S Pear,
  • Eric Lancaster

DOI
https://doi.org/10.1371/journal.pone.0161157
Journal volume & issue
Vol. 11, no. 9
p. e0161157

Abstract

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Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling, and bound Notch-fc in a cell-based assay. DNER is not a Notch ligand and its true function remains unknown.