Nature Communications (Feb 2018)
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
- Will J. R. Stone,
- Joseph J. Campo,
- André Lin Ouédraogo,
- Lisette Meerstein-Kessel,
- Isabelle Morlais,
- Dari Da,
- Anna Cohuet,
- Sandrine Nsango,
- Colin J. Sutherland,
- Marga van de Vegte-Bolmer,
- Rianne Siebelink-Stoter,
- Geert-Jan van Gemert,
- Wouter Graumans,
- Kjerstin Lanke,
- Adam D. Shandling,
- Jozelyn V. Pablo,
- Andy A. Teng,
- Sophie Jones,
- Roos M. de Jong,
- Amanda Fabra-García,
- John Bradley,
- Will Roeffen,
- Edwin Lasonder,
- Giuliana Gremo,
- Evelin Schwarzer,
- Chris J. Janse,
- Susheel K. Singh,
- Michael Theisen,
- Phil Felgner,
- Matthias Marti,
- Chris Drakeley,
- Robert Sauerwein,
- Teun Bousema,
- Matthijs M. Jore
Affiliations
- Will J. R. Stone
- Radboud Institute for Health Sciences, Radboud University Medical Center
- Joseph J. Campo
- Antigen Discovery Inc.
- André Lin Ouédraogo
- Institute for Disease Modeling
- Lisette Meerstein-Kessel
- Radboud Institute for Health Sciences, Radboud University Medical Center
- Isabelle Morlais
- Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale
- Dari Da
- Institut de Recherche en Sciences de la Santé
- Anna Cohuet
- Institut de Recherche pour le Développement, MIVEGEC (IRD, CNRS, Univ. Montpellier)
- Sandrine Nsango
- Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale
- Colin J. Sutherland
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- Marga van de Vegte-Bolmer
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Rianne Siebelink-Stoter
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Geert-Jan van Gemert
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Wouter Graumans
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Kjerstin Lanke
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Adam D. Shandling
- Antigen Discovery Inc.
- Jozelyn V. Pablo
- Antigen Discovery Inc.
- Andy A. Teng
- Antigen Discovery Inc.
- Sophie Jones
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- Roos M. de Jong
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Amanda Fabra-García
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- John Bradley
- Medical Research Council Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine
- Will Roeffen
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Edwin Lasonder
- School of Biomedical and Healthcare Sciences, Plymouth University, Drakes Circus
- Giuliana Gremo
- Department of Oncology, University of Torino
- Evelin Schwarzer
- Department of Oncology, University of Torino
- Chris J. Janse
- Department of Parasitology, Leiden University Medical Center (LUMC)
- Susheel K. Singh
- Department for Congenital Diseases, Statens Serum Institut
- Michael Theisen
- Department for Congenital Diseases, Statens Serum Institut
- Phil Felgner
- Department of Medicine, University of California Irvine
- Matthias Marti
- Department of Immunology and Infectious Diseases, Harvard School of Public Health
- Chris Drakeley
- Department of Immunology and Infection, London School of Hygiene and Tropical Medicine
- Robert Sauerwein
- Radboud Institute for Health Sciences, Radboud University Medical Center
- Teun Bousema
- Radboud Institute for Health Sciences, Radboud University Medical Center
- Matthijs M. Jore
- Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- DOI
- https://doi.org/10.1038/s41467-017-02646-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.
