Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Christos Karampelias; Habib Rezanejad; Mandy Rosko; Likun Duan; Jing Lu; Laura Pazzagli; Philippe Bertolino; Carolyn E. Cesta; Xiaojing Liu; Gregory S. Korbutt; Olov Andersson

doi:10.1038/s41467-021-23673-0

Nature Communications (Jun 2021)

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Christos Karampelias,
Habib Rezanejad,
Mandy Rosko,
Likun Duan,
Jing Lu,
Laura Pazzagli,
Philippe Bertolino,
Carolyn E. Cesta,
Xiaojing Liu,
Gregory S. Korbutt,
Olov Andersson

Affiliations

Christos Karampelias: Department of Cell and Molecular Biology, Karolinska Institutet
Habib Rezanejad: Department of Surgery and Alberta Diabetes Institute, University of Alberta
Mandy Rosko: Department of Surgery and Alberta Diabetes Institute, University of Alberta
Likun Duan: Department of Molecular and Structural Biochemistry, NC State University
Jing Lu: Department of Cell and Molecular Biology, Karolinska Institutet
Laura Pazzagli: Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet
Philippe Bertolino: Cancer Research Centre of Lyon, INSERM U1052, CNRS UMR5286, Claude Bernard University
Carolyn E. Cesta: Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet
Xiaojing Liu: Department of Molecular and Structural Biochemistry, NC State University
Gregory S. Korbutt: Department of Surgery and Alberta Diabetes Institute, University of Alberta
Olov Andersson: Department of Cell and Molecular Biology, Karolinska Institutet

DOI: https://doi.org/10.1038/s41467-021-23673-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta-cell regeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal