Intraoperative challenges after induction therapy for non–small cell lung cancer: Effect of nodal disease on technical complexityCentral MessagePerspective
Hope A. Feldman, MD,
Nicolas Zhou, DO,
Nathanial Deboever, MD,
Wayne Hofstetter, MD,
Reza Mehran, MD,
Ravi Rajaram, MD,
David Rice, MD,
Jack A. Roth, MD,
Boris Sepesi, MD,
Stephen Swisher, MD,
Ara Vaporciyan, MD,
Garrett Walsh, MD,
Myrna Godoy, MD, PhD,
Chad Strange, MD,
Mara B. Antonoff, MD
Affiliations
Hope A. Feldman, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Nicolas Zhou, DO
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Nathanial Deboever, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Wayne Hofstetter, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Reza Mehran, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Ravi Rajaram, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
David Rice, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Jack A. Roth, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Boris Sepesi, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Stephen Swisher, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Ara Vaporciyan, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Garrett Walsh, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex
Myrna Godoy, MD, PhD
Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex
Chad Strange, MD
Department of Thoracic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex
Mara B. Antonoff, MD
Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex; Address for reprints: Mara B. Antonoff, MD, Thoracic and Cardiovascular Surgery, 1400 Pressler St, Unit 1489, Houston, TX 77030.
Objectives: Neoadjuvant therapy has been theorized to increase complexity of non–small cell lung cancer resections; however, specific factors that contribute to intraoperative challenges after induction therapy have not been well described. We aimed to characterize the effect of nodal involvement and nodal treatment response on surgical complexity after neoadjuvant therapy. Methods: We identified patients treated with neoadjuvant therapy followed by anatomic lung resection for cN + non–small cell lung cancer between 2010 and 2020. Patients were categorized according to clinical N1 versus N2 disease. To evaluate the effect of nodal response to therapy, thoracic radiologists measured clinically suspected and pathologically involved lymph nodes before and after induction therapy. Operative reports were reviewed to identify technical challenges specifically related to nodal disease. Categorical outcomes were compared using Fisher exact test. Results: One hundred twenty-four patients met inclusion criteria, among whom 107 (86.3%) were treated with neoadjuvant chemotherapy, whereas chemoradiation (n = 8) and targeted therapy (n = 9) were less common. In cases with N1 disease, 8/38 (21.0%) required proximal pulmonary arterial control, whereas this was necessary in only 2/88 (2.3%) of N2 cases (P = .001). Likewise, sleeve resection and arterioplasty were needed more frequently during resection of N1 disease (7/38, 18.4%) versus N2 disease (0/88, P < .001). Increased nodal response to therapy was associated with greater likelihood of requiring change in vascular approach (P = .011). Conclusions: After induction therapy, N1 disease was associated with greater need for complex surgical maneuvers than N2 disease. Likewise, substantial treatment response was associated with increased intraoperative technical challenges. Recognizing such factors enables surgical teams to engage in appropriate operative planning to ensure patient safety.
