Journal of Blood Medicine (Feb 2023)
Serum Ferritin Levels and Other Associated Parameters with Diabetes Mellitus in Adult Patients Suffering from Beta Thalassemia Major
Abstract
Ahmed Saleh Ibrahim,1 Azza Hasan Abd El-Fatah,2 Ayman Fathy Abd El-Halim,3 Farid Fawzy Mohamed2 1Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 2Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt; 3Department of Hematology, Faculty of Medicine, Zagazig University, Zagazig, EgyptCorrespondence: Ahmed Saleh Ibrahim, Tel +20 109 232 6689, Email [email protected]: Although beta thalassemia major (BTM) patients are properly treated with blood transfusions in accompany with iron chelation therapy, they suffer from complications, such as diabetes mellitus (DM).Purpose: The purpose was to detect the critical serum ferritin level and other parameters correlated with DM among adult BTM patients. Also, it was to study whether each of these parameters is associated with a certain period of age.Patients and Methods: This study included 200 adult BTM patients. A cross-sectional study was carried out. Patients clinical and laboratory variables, such as ferritin levels, and fasting blood glucose (FBS) were extracted from medical records at Zagazig University Hospital, Egypt. Liver and cardiac iron contents were assessed using MRI T2* methods. Statistical analysis was performed using IBM SPSS V26.0 software package.Results: The overall frequency of DM over the total sample equals 6.5%. There were no impaired fasting glucose (IFG) in the medical records. Statistical significance between serum ferritin and DM was (P = 0.014). The serum ferritin 2500 ng/mL with age group (27– 2500 ng/mL should be properly treated immediately. The serum ferritin and BMI of class “overweight” were risk factors for DM. Factors such as diet should be followed. Serum ferritin can be used for estimating liver iron content for economic factors. But cardiac MRI T2* must be performed for evaluating cardiac iron accurately.Keywords: hemoglobin, iron chelation, blood glucose, endocrinopathy
