Synthesis and Characterization of New Spiroheterocyclic from Isatin and Evaluation of Some Their Antifungal and Antibacterial Activity

Abstract

Spiro compounds Spiro cycles are widely found in natural products, medicines, and functional materials[1] the spiro atom forces the planes of the two rings to almost face one another, spiro compounds are a desirable subclass of heterocyclic scaffolds. In particular, spiropyrrolidine analogs are present in many naturally occurring products as well as in synthetic compounds that are important for biological processes, and they have a variety of biological and pharmacological effectsThe present investigation introduced six chalcon , featured by substituted acetophenone and substituted benzaldehyde. These chalcon were utilized to prepare six compounds of Hetero spiro cyclic . The reactions were watched with thin layer chromatography (TLC) and all structures were characterized utilizing spectroscopy techniques like Fourier-transform infrared spectroscopy (FTIR) and some of them were characterized by Proton nuclear magnetic resonance (1H-NMR), Carbon nuclear magnetic resonance (13C-NMR), and mass spectroscopy analysis techniques, and Study of the biological effectiveness of spiroheterocyclic compounds prepared against bacteria and fungi.

Keywords

• spiro heterocyclic compounds
• natural products
• vitamins
• hormones
• alkaloids