Elevated neutrophil - to - monocyte ratio as a prognostic marker for poor outcomes in neonatal sepsis
Xiaohong Xia,
Yaman Wang,
Mengxiao Xie,
Shengfeng Qiu,
Jun Zhou
Affiliations
Xiaohong Xia
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, Jiangsu, China
Yaman Wang
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, Jiangsu, China
Mengxiao Xie
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, Jiangsu, China
Shengfeng Qiu
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, Jiangsu, China; Corresponding author.
Jun Zhou
Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, Jiangsu, China; Corresponding author.
Objectives: Neonatal sepsis is one of the leading causes of neonatal death. The aim of this study was to evaluate the value of neutrophil - to - monocyte ratio (NMR) in predicting mortality in neonatal sepsis. Methods: In this present retrospective study, a total of 134 neonates with sepsis were included. Baseline laboratory parameters were collected. The best cutoff value of NMR was determined by receiver operating characteristic (ROC) curve. Univariate and multivariate analysis were carried out to survey the predict value of NMR. Results: The results showed that NMR in non-survival group was significantly higher than that in survival group. Results from multivariate analysis showed that high NMR was an independent risk factor for neonatal sepsis (Hazard ratio (HR): 7.519, p = 0.001). ROC displayed that the area under curve (AUC) of NMR was 0.740, sensitivity and specificity of NMR were 80% and 65.8% when 7.65 was selected. Conclusions: NMR could be a promising prognostic factor for neonatal sepsis.
