Nature Communications (Jul 2019)

Single-cell reconstruction of follicular remodeling in the human adult ovary

  • X. Fan,
  • M. Bialecka,
  • I. Moustakas,
  • E. Lam,
  • V. Torrens-Juaneda,
  • N. V. Borggreven,
  • L. Trouw,
  • L. A. Louwe,
  • G. S. K. Pilgram,
  • H. Mei,
  • L. van der Westerlaken,
  • S. M. Chuva de Sousa Lopes

DOI
https://doi.org/10.1038/s41467-019-11036-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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In the ovary, follicular degeneration occurs after folliculogenesis, with one dominant follicle reaching maturity every month. Here, by performing single cell RNA-seq of adult human follicles, the authors identify subclasses of granulosa and theca cell lineages, which correlate with the growth or degeneration of the follicles.