Revista da Sociedade Brasileira de Medicina Tropical (Nov 2020)

HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

  • Gemilson Soares Pontes,
  • Hygor Halyson Figueiredo Ribeiro,
  • Diana Mota Toro,
  • José Pereira de Moura Neto,
  • Victor Souza,
  • Maria Edilene Martins de Almeida,
  • Valdinete Alves do Nascimento,
  • Cristovão Alves da Costa,
  • Felipe Gomes Naveca,
  • Mike Santos,
  • Antonio Carlos Rosário Vallinoto

DOI
https://doi.org/10.1590/0037-8682-0066-2020
Journal volume & issue
Vol. 54

Abstract

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Abstract INTRODUCTION: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region. RESULTS: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype. CONCLUSIONS: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil’s western Amazon region.

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