Nature Communications (Apr 2018)

The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

  • Gabriele Stephan,
  • Lumei Huang,
  • Yong Tang,
  • Sandra Vilotti,
  • Elsa Fabbretti,
  • Ye Yu,
  • Wolfgang Nörenberg,
  • Heike Franke,
  • Flóra Gölöncsér,
  • Beáta Sperlágh,
  • Anke Dopychai,
  • Ralf Hausmann,
  • Günther Schmalzing,
  • Patrizia Rubini,
  • Peter Illes

DOI
https://doi.org/10.1038/s41467-018-03728-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 18

Abstract

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Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents.