The effect of vitamin D3 on improving lipid profile, fasting glucose and insulin resistance in polycystic ovary syndrome women with vitamin D deficiency

Abstract

Introduction: Metabolic disturbances are common in women with PCOS. Some studies have suggested that vitamin D deficiency may play a role in metabolic disorders and insulin resistance, although limited clinical trials on this subject have been published with contradictory findings. Therefore, the aim of this study was to investigate the effects of vitamin D on metabolic disorders in women with PCOS and vitamin D deficiency. Methods: This study was a randomized-blinded clinical trial. Eighty-six women diagnosed with PCOS and vitamin D deficiency aged between 18 and 45 were enrolled. They were randomly divided into two groups of interventional (44 women) and control (42 women). In each group, patient assignment was done using randomized blocks of four. Based on the block combination, vitamin D at a dose of 50,000 unit per week (Interventional group) and a dose of 50,000 units per month (Control group) and elemental calcium at a dose of 1000 mg per day were administered by a nurse. Metabolic parameters (i.e., LDL, HDL, total cholesterol, HOMA-IR, serum insulin, FBS, TG) and serum vitamin D were measured at baseline and 2 months after treatment. Results: In vitamin D group, serum levels of 25 (OH) D increased. There was no significant difference in the metabolic parameters before and after treatment in each group (P > .05). At the end of the study, the metabolic parameters and HOMA-IR did not show a significant difference. Conclusion: This study showed that vitamin D replacement in women with PCOS and vitamin D deficiency has no effect on the improvement of metabolic parameters and HOMA-IR. Keywords: Polycystic ovary syndrome, Vitamin D