Journal of Epidemiology (Nov 2020)

Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study

  • Shiho Amagasa,
  • Shigeru Inoue,
  • Hiroshi Murayama,
  • Takeo Fujiwara,
  • Hiroyuki Kikuchi,
  • Noritoshi Fukushima,
  • Masaki Machida,
  • Sebastien Chastin,
  • Neville Owen,
  • Yugo Shobugawa

DOI
https://doi.org/10.2188/jea.JE20190141
Journal volume & issue
Vol. 30, no. 11
pp. 503 – 508

Abstract

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Background: Physical activity can help to protect against cognitive decline in older adults. However, little is known about the potential combined relationships of time spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with indices of cognitive health. We examined the cross-sectional associations of objectively-determined sedentary and physically-active behaviors with an indicator of cognitive function decline (CFD) in older adults. Methods: A randomly-recruited sample of 511 Japanese older adults (47% male; aged 65–84 years) wore a tri-axial accelerometer for 7 consecutive days in 2017. Cognitive function was assessed by interviewers using the Japanese version of Mini-Mental State Examination, with a score of ≤23 indicating CFD. Associations of sedentary and physically-active behaviors with CFD were examined using a compositional logistic regression analysis based on isometric log-ratio transformations of time use, adjusting for potential confounders. Results: Forty one (9.4%) of the participants had an indication of CFD. Activity compositions differed significantly between CFD and normal cognitive function (NCF); the proportion of time spent in MVPA was 39.1% lower, relative to the overall mean composition in those with CFD, and was 5.3% higher in those with NCF. There was a significant beneficial association of having a higher proportion of MVPA relative to other activities with CFD. LPA and SB were not associated with CFD when models were corrected for time spent in all activity behaviors. Conclusions: Larger relative contribution of MVPA was favorably associated with an indicator of CFD in older adults.

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