Российский кардиологический журнал (Aug 2014)

THE INFLUENCE OF ENDOTHELIUM-DEPENDENT MECHANISMS OF VESSEL TONE REGULATION ON THE TISSUE OXYGENATION PARAMETERS IN PATIENTS WITH ISCHEMIC STROKE AT THE BACKGROUND OF ARTERIAL HYPERTENSION SYNDROME

  • A. Yu. Ryabchenko,
  • A. M. Dolgov,
  • E. N. Denisov,
  • N. G. Gumanova

DOI
https://doi.org/10.15829/1560-4071-2014-8-49-52
Journal volume & issue
Vol. 0, no. 8
pp. 49 – 52

Abstract

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Aim. To study properties of tissue oxygenation and role of nitricoxyde-ergic reactions of circulation in ischemic stroke at the background of arterial hypertension. Material and methods. Totally 62 men and women included with the diagnosis of ischemic stroke. All patients underwent CT and MRI of the brain; cerebral flow was studied by extra- and transcranial ultrasound dopplerography, central hemodynamics was assessed by echocardiography, the basic clinical tests performed, and neurological and neuroophthalmological examination. Study of oxygen transport on the microcirculatory level was performed by polarographic method by transcutaneous measurement of oxygen pressure in tissues. Gases of the blood were measured on the analyzer Easy Stat "Medica Corporation" (USA). For the evaluation of nitric oxide (NO) level, we used the measurements of its stabile metabolites on blood — nitrites and nitrates. Neurological status was examined with the NIHSS score (The Score of the National Health Institute of the US, by T Brot, H.R Adams, 1989). All patients studied were then grouped into 3 groups according to severity of the stroke. Mathematical analysis was performed using software "Statistica 6.0" with non-parametric criteria of Mann-Whitney. Significant were the data with p<0,05.Results. In patients with ischemic stroke, there were disorders of nitricoxide-ergic mechanism of the vessels. Decrease of the level of stable NO metabolites and impairment of tissue oxygenation were linked to the severity of the disease and prominence of neurologic deficiency.Conclusion. In ischemic stroke, there are structural and functional changes in cerebral vessels, which do worsen by the impairment of systemic circulation, increase of systemic pressure, those then lead to tissue hypoxia and neurologic deficiency progression.

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