Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

Huating Li; Guangyu Wu; Qichen Fang; Mingliang Zhang; Xiaoyan Hui; Bin Sheng; Liang Wu; Yuqian Bao; Peng Li; Aimin Xu; Weiping Jia

doi:10.1038/s41467-017-02677-9

Nature Communications (Jan 2018)

Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat

Huating Li,
Guangyu Wu,
Qichen Fang,
Mingliang Zhang,
Xiaoyan Hui,
Bin Sheng,
Liang Wu,
Yuqian Bao,
Peng Li,
Aimin Xu,
Weiping Jia

Affiliations

Huating Li: Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Guangyu Wu: Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Qichen Fang: Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Mingliang Zhang: Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Xiaoyan Hui: State Key Laboratory of Pharmaceutical Biotechnology
Bin Sheng: Department of Computer Science and Engineering, Shanghai Jiao Tong University
Liang Wu: Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Yuqian Bao: Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Peng Li: Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Aimin Xu: State Key Laboratory of Pharmaceutical Biotechnology
Weiping Jia: Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital

DOI: https://doi.org/10.1038/s41467-017-02677-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

Read online

FGF21 has a number of beneficial metabolic effects. Here, Li et al. show that FGF21 promotes the healthy expansion of subcutaneous white adipose tissue, promoting the healthy expansion of fat tissue as a regulatory mechanism to maintain systemic insulin sensitivity during nutrient excess.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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