Nature Communications (Jan 2016)

Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells

  • Lee M. Butcher,
  • Mitsuteru Ito,
  • Minodora Brimpari,
  • Tiffany J. Morris,
  • Filipa A. C. Soares,
  • Lars Ährlund-Richter,
  • Nessa Carey,
  • Ludovic Vallier,
  • Anne C. Ferguson-Smith,
  • Stephan Beck

DOI
https://doi.org/10.1038/ncomms10458
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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The methylation of non-CpG residues is a poorly understood marker of pluripotent cells, gradually lost as cells differentiate. Here the authors show non-CG methylation can be used as a marker of differentiation potential.