Nature Communications (May 2020)
Effective combinatorial immunotherapy for penile squamous cell carcinoma
- Tianhe Huang,
- Xi Cheng,
- Jad Chahoud,
- Ahmed Sarhan,
- Pheroze Tamboli,
- Priya Rao,
- Ming Guo,
- Ganiraju Manyam,
- Li Zhang,
- Yu Xiang,
- Leng Han,
- Xiaoying Shang,
- Pingna Deng,
- Yanting Luo,
- Xuemin Lu,
- Shan Feng,
- Magaly Martinez Ferrer,
- Y. Alan Wang,
- Ronald A. DePinho,
- Curtis A. Pettaway,
- Xin Lu
Affiliations
- Tianhe Huang
- Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame
- Xi Cheng
- Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame
- Jad Chahoud
- Department of Cancer Medicine, The University of Texas MD Anderson Cancer Center
- Ahmed Sarhan
- Department of Urology, The University of Texas MD Anderson Cancer Center
- Pheroze Tamboli
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Priya Rao
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Ming Guo
- Department of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center
- Ganiraju Manyam
- Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center
- Li Zhang
- Department of Environmental Health, University of Cincinnati
- Yu Xiang
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School
- Leng Han
- Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School
- Xiaoying Shang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Pingna Deng
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Yanting Luo
- Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame
- Xuemin Lu
- Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame
- Shan Feng
- Mass Spectrometry Core Facility, School of Life Sciences, Westlake University, Hangzhou
- Magaly Martinez Ferrer
- Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico
- Y. Alan Wang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Ronald A. DePinho
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Curtis A. Pettaway
- Department of Urology, The University of Texas MD Anderson Cancer Center
- Xin Lu
- Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame
- DOI
- https://doi.org/10.1038/s41467-020-15980-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Penile squamous cell carcinoma (PSCC) is a cancer that is associated with significant mortality. Here, the authors develop a mouse model of PSCC by co-deletion of Smad4 and Apc in the androgen-responsive penile epithelium, and show synergistic efficacy of checkpoint therapy with cabozantinib or celecoxib in their model.
