Nature Communications (Nov 2018)
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
- Mauricio S. Caetano,
- Maya Hassane,
- Hieu T. Van,
- Emmanuel Bugarin,
- Amber M. Cumpian,
- Christina L. McDowell,
- Carolina Gonzalez Cavazos,
- Huiyuan Zhang,
- Shanshan Deng,
- Lixia Diao,
- Jing Wang,
- Scott E. Evans,
- Carmen Behrens,
- Ignacio I. Wistuba,
- Susan A. W. Fuqua,
- Huang Lin,
- Laura P. Stabile,
- Stephanie S. Watowich,
- Humam Kadara,
- Seyed Javad Moghaddam
Affiliations
- Mauricio S. Caetano
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Maya Hassane
- Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut
- Hieu T. Van
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Emmanuel Bugarin
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Amber M. Cumpian
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Christina L. McDowell
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Carolina Gonzalez Cavazos
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Huiyuan Zhang
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Shanshan Deng
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Lixia Diao
- Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center
- Jing Wang
- Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center
- Scott E. Evans
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- Carmen Behrens
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Susan A. W. Fuqua
- Lester and Sue Smith Breast Center, Baylor College of Medicine
- Huang Lin
- Department of Biostatistics, UPMC Hillman Cancer Center, University of Pittsburgh
- Laura P. Stabile
- Department of Pharmacology & Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh
- Stephanie S. Watowich
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Humam Kadara
- Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut
- Seyed Javad Moghaddam
- Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-07042-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-specific role for epithelial Stat3 signaling in K-ras-mutant LUAD.
