Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid

Yuhan Jiang; Yixiao Li; Cheng Liu; Lei Zhang; Danyu Lv; Yejing Weng; Zhongyi Cheng; Xiangmei Chen; Jun Zhan; Hongquan Zhang

doi:10.1038/s41467-021-25867-y

Nature Communications (Sep 2021)

Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid

Yuhan Jiang,
Yixiao Li,
Cheng Liu,
Lei Zhang,
Danyu Lv,
Yejing Weng,
Zhongyi Cheng,
Xiangmei Chen,
Jun Zhan,
Hongquan Zhang

Affiliations

Yuhan Jiang: Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, PKU International Cancer Institute, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center
Yixiao Li: Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, PKU International Cancer Institute, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center
Cheng Liu: Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, PKU International Cancer Institute, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center
Lei Zhang: Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, PKU International Cancer Institute, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center
Danyu Lv: Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, PKU International Cancer Institute, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center
Yejing Weng: Jingjie PTM BioLab Co. Ltd., Hangzhou Economic and Technological Development Area
Zhongyi Cheng: Jingjie PTM BioLab Co. Ltd., Hangzhou Economic and Technological Development Area
Xiangmei Chen: Department of Microbiology & Infectious Disease Center, Peking University Health Science Center
Jun Zhan: Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, PKU International Cancer Institute, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center
Hongquan Zhang: Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, PKU International Cancer Institute, MOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center

DOI: https://doi.org/10.1038/s41467-021-25867-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Isoniazid (INH) is an anti-tuberculosis drug; however the underlying cause of its various side effects are not understood. Here the authors identified lysine isonicotinylation as a histone modification on chromatin that is metabolically regulated by INH and its metabolites.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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