Nature Communications (Jun 2021)
Extracellular mRNA transported to the nucleus exerts translation-independent function
- Takeshi Tomita,
- Masayoshi Kato,
- Taishi Mishima,
- Yuta Matsunaga,
- Hideki Sanjo,
- Ken-ichi Ito,
- Kentaro Minagawa,
- Toshimitsu Matsui,
- Hiroyuki Oikawa,
- Satoshi Takahashi,
- Toshifumi Takao,
- Noriki Iwai,
- Takashi Mino,
- Osamu Takeuchi,
- Yoshiro Maru,
- Sachie Hiratsuka
Affiliations
- Takeshi Tomita
- Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, School of Medicine
- Masayoshi Kato
- Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, School of Medicine
- Taishi Mishima
- Department of Pharmacology, Tokyo Women’s Medical University
- Yuta Matsunaga
- Department of Pharmacology, Tokyo Women’s Medical University
- Hideki Sanjo
- Department of Molecular and Cellular Immunology, Shinshu University, School of Medicine
- Ken-ichi Ito
- Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery, Shinshu University, School of Medicine
- Kentaro Minagawa
- Department of Hematology/Oncology, Penn State College of Medicine
- Toshimitsu Matsui
- Department of Hematology, Nishiwaki Municipal Hospital
- Hiroyuki Oikawa
- Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
- Satoshi Takahashi
- Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
- Toshifumi Takao
- Institute for Protein Research, Osaka University
- Noriki Iwai
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Takashi Mino
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Osamu Takeuchi
- Department of Medical Chemistry, Graduate School of Medicine, Kyoto University
- Yoshiro Maru
- Department of Pharmacology, Tokyo Women’s Medical University
- Sachie Hiratsuka
- Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23969-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.
