Nature Communications (Sep 2017)

RETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer

  • Anthony Alioui,
  • Julie Dufour,
  • Valerio Leoni,
  • Anke Loregger,
  • Martina Moeton,
  • Luigi Iuliano,
  • Chiara Zerbinati,
  • Amandine Septier,
  • Pierre Val,
  • Allan Fouache,
  • Vincenzo Russo,
  • David H. Volle,
  • Jean-Marc A. Lobaccaro,
  • Noam Zelcer,
  • Silvère Baron

DOI
https://doi.org/10.1038/s41467-017-00508-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Treatment of prostate cancer, especially in its advanced stage, is still challenging; therefore, strategies to prevent metastatic dissemination are of great interest. Here the authors reveal a crucial role for liver X receptors in suppressing prostate carcinogenesis and metastatic progression in PTEN-null tumors.