Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki (Dec 2017)
Circulative biomarkers as predictors of cardiovascular events in patients after treatment of Hodgkin lymphoma
Abstract
Aim. Nature development of lymphoma associates with increased risk of cardiovascular diseases. We aimed to evaluate the prognostic value of circulating NT-proBNP, galectin-3, and VE-cadherin in survivors of Hodgkin lymphoma. Methods: Surveys were given to Hodgkin lymphoma survivors who reached at list partial response after treatment. Observation period was up to 3 years. ELISA method for measurements of circulating level of biomarkers was used. Results: During observation period progression of Hodgkin lymphoma was proved in 8 patients, 4 persons were excluded for poor follow-up. Thirty four cumulative clinical events occurred in 11 patients (55%) within the follow-up, with their distribution being as follows: 2 cardiovascular deaths, 16 cardiac arrhythmias, 6 cardiac ischemic events, 1 stroke, 4 chronic heart failures and 5 hospital admissions for cardiovascular reasons. 4 deaths were not related with cardiovascular pathology or cardiovascular reasons. Circulating level of NT-proBNP in patients without cardiovascular events and with cardiovascular events were 5.81 pg/ml (95% confidence interval [CI] = 3.21-8.41 pg/ml) and 12.74 pg/ml (95 % CI = 6.47-18.94 pg/ml) (р=0.072). In patients without cardiovascular events circulating level of galectin-3 was 5.91 pg/ml (95% confidence interval [CI] = 4.18-7.03 pg/ml) and in patients with cardiovascular events circulating level of galectin-3 was 14.33 pg/ml (95% CI = 5.99-16.18 pg/ml) (р=0.01). Circulating level of VE-cadherin in patients without cardiovascular events and with cardiovascular events were 0.40 pg/ml (95% confidence interval [CI] = 0.31-0.54 pg/ml) and 0.99 pg/ml (95% CI = 0.70-1.15 pg/ml) (р=0.02) In multivariate logistic regression circulating NT-proBNP independently predicted cumulative cardiovascular events (odds ratio [OR] = 1,179; 95% CI = 1,043–1,334; р = 0.008) within 3 years of observation period. Conclusion: Among patients after treatment of Hodgkin lymphoma increased circulating NT-proBNP may associate with increased cumulative cardiovascular events during 3 years.
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