Nature Communications (Aug 2021)
Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis
- Xunyao Wu,
- Yi Liu,
- Shanzhao Jin,
- Min Wang,
- Yuhao Jiao,
- Bo Yang,
- Xin Lu,
- Xin Ji,
- Yunyun Fei,
- Huaxia Yang,
- Lidan Zhao,
- Hua Chen,
- Yaran Zhang,
- Hao Li,
- Peter E. Lipsky,
- George C. Tsokos,
- Fan Bai,
- Xuan Zhang
Affiliations
- Xunyao Wu
- Clinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yi Liu
- Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University
- Shanzhao Jin
- Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University
- Min Wang
- Clinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yuhao Jiao
- Clinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Bo Yang
- Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Xin Lu
- Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Xin Ji
- Clinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Yunyun Fei
- Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory
- Huaxia Yang
- Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory
- Lidan Zhao
- Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory
- Hua Chen
- Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, The Ministry of Education Key Laboratory
- Yaran Zhang
- Clinical Immunology Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Hao Li
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Peter E. Lipsky
- RILITE Research Institute and AMPEL BioSolutions
- George C. Tsokos
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Fan Bai
- Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University
- Xuan Zhang
- Department of Rheumatology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences
- DOI
- https://doi.org/10.1038/s41467-021-25246-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Patients with rheumatoid arthritis are commonly stratified by ACPA serology, with positivity being associated with more severe disease and joint destruction. Here the authors present a single cell RNA sequencing resource comparing peripheral blood and synovial tissue cells from patients with ACPA+ versus ACPA- rheumatoid arthritis.
