Nature Communications (Feb 2018)

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

  • Sarah Cohen,
  • Nadine Puget,
  • Yea-Lih Lin,
  • Thomas Clouaire,
  • Marion Aguirrebengoa,
  • Vincent Rocher,
  • Philippe Pasero,
  • Yvan Canitrot,
  • Gaëlle Legube

DOI
https://doi.org/10.1038/s41467-018-02894-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Recent studies suggest key roles of RNA in DNA double-strand breaks repair. Here the authors identify the helicase senataxin to be involved in DNA repair and resolve RNA:DNA hybrids forming at DNA double-strand breaks.