Recent Advances in the Development of Magnesium-Based Alloy Guided Bone Regeneration (GBR) Membrane
Kai Chen,
Li Zhao,
Chenyang Huang,
Xiaofei Yin,
Xiaobo Zhang,
Ping Li,
Xuenan Gu,
Yubo Fan
Affiliations
Kai Chen
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
Li Zhao
Beijing Advanced Innovation Center for Materials Genome Engineering, Institute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing 100083, China
Chenyang Huang
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
Xiaofei Yin
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
Xiaobo Zhang
School of Materials Science and Engineering, Nanjing Institute of Technology, Nanjing 211167, China
Ping Li
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
Xuenan Gu
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
Yubo Fan
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
In dental implantology, the guided bone regeneration (GBR) membrane plays an active role in increasing alveolar bone volume. However, there are some drawbacks to the current commercial membranes, such as non-degradability for non-absorbable membranes and low mechanical strength for absorbable membranes. Recently, magnesium (Mg) alloys have been proposed as potential barrier membrane candidates. As a result, the purpose of this research is to assess the feasibility of Mg alloys as GBR membranes in terms of physicochemical properties and biological performance. Mg alloys were identified as potential membrane materials due to their adjustable degradation, adequate mechanical support, sound osteogenic property, good bacteriostatic activity, and favorable wound-healing ability. Nonetheless, rapid degradation and stress corrosion cracking (SCC)/corrosion fatigue (CF) are major concerns for the use of Mg-based membranes, which can be mitigated through alloying, heat treatment, thermomechanical deformation, and other methods. Finally, the prospects for the design and manufacture of Mg-based membranes in the future were put forth.
