Nature Communications (Oct 2018)

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

  • Yuan Liu,
  • Ji-Zheng Guo,
  • Ying Liu,
  • Kui Wang,
  • Wencheng Ding,
  • Hui Wang,
  • Xiang Liu,
  • Shengtao Zhou,
  • Xiao-Chen Lu,
  • Hong-Bin Yang,
  • Chenyue Xu,
  • Wei Gao,
  • Li Zhou,
  • Yi-Ping Wang,
  • Weiguo Hu,
  • Yuquan Wei,
  • Canhua Huang,
  • Qun-Ying Lei

DOI
https://doi.org/10.1038/s41467-018-06841-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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High-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and current evidences link E7 to HPV-associated carcinogenesis. Here the authors propose a model in which the infection of epithelial cells with high risk HPV results in a burst of reactive oxygen species, translocation of LDHA to the nucleus and activation of a gene profile that supports the growth of cervical cancer.