Pathology and Oncology Research (Apr 2022)

Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia

  • Zsófia F. Nagy,
  • Kata Ferenczi,
  • Ildikó Istenes,
  • Hanna Eid,
  • Csaba Bödör,
  • Botond Timár,
  • Judit Demeter

DOI
https://doi.org/10.3389/pore.2022.1610338
Journal volume & issue
Vol. 28

Abstract

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Hairy cell leukaemia (HCL) is a rare B cell malignancy with an indolent course leading to pancytopaenia due to bone marrow infiltration. It has been proposed that HCL patients are at risk of developing a secondary malignancy, with a marked likelihood of the development of other hematologic malignancies including Hodgkin lymphoma and high-grade non-Hodgkin lymphomas. Here, we present the case of two patients who developed diffuse large B cell lymphoma after a long course of hairy cell leukaemia. In the case of the female patient, we report on the occurrence of a third malignant disease, which is very uncommon. With our case descriptions we contribute to the very small number of similar cases reported.

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