Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to the development of osteoarthritis

• Tim Rolvien,
• Timur A. Yorgan,
• Uwe Kornak,
• Irm Hermans-Borgmeyer,
• Stefan Mundlos,
• Tobias Schmidt,
• Andreas Niemeier,
• Thorsten Schinke,
• Michael Amling,
• Ralf Oheim

Affiliations

Tim Rolvien

Department of Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Corresponding author.

Timur A. Yorgan

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Uwe Kornak

Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin, Berlin, Germany

Irm Hermans-Borgmeyer

Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Stefan Mundlos

Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin, Berlin, Germany

Tobias Schmidt

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Andreas Niemeier

Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Thorsten Schinke

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Michael Amling

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Ralf Oheim

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany