Nature Communications (May 2019)
Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
- Yi Zhang,
- Younghoon Jang,
- Ji-Eun Lee,
- JaeWoo Ahn,
- Longxia Xu,
- Michael R. Holden,
- Evan M. Cornett,
- Krzysztof Krajewski,
- Brianna J. Klein,
- Shu-Ping Wang,
- Yali Dou,
- Robert G. Roeder,
- Brian D. Strahl,
- Scott B. Rothbart,
- Xiaobing Shi,
- Kai Ge,
- Tatiana G. Kutateladze
Affiliations
- Yi Zhang
- Department of Pharmacology, University of Colorado School of Medicine
- Younghoon Jang
- Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
- Ji-Eun Lee
- Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
- JaeWoo Ahn
- Department of Pharmacology, University of Colorado School of Medicine
- Longxia Xu
- Center for Epigenetics, Van Andel Research Institute
- Michael R. Holden
- Department of Pharmacology, University of Colorado School of Medicine
- Evan M. Cornett
- Center for Epigenetics, Van Andel Research Institute
- Krzysztof Krajewski
- Department of Biochemistry & Biophysics, The University of North Carolina School of Medicine
- Brianna J. Klein
- Department of Pharmacology, University of Colorado School of Medicine
- Shu-Ping Wang
- Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
- Yali Dou
- Department of Pathology, University of Michigan
- Robert G. Roeder
- Laboratory of Biochemistry and Molecular Biology, The Rockefeller University
- Brian D. Strahl
- Department of Biochemistry & Biophysics, The University of North Carolina School of Medicine
- Scott B. Rothbart
- Center for Epigenetics, Van Andel Research Institute
- Xiaobing Shi
- Center for Epigenetics, Van Andel Research Institute
- Kai Ge
- Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
- Tatiana G. Kutateladze
- Department of Pharmacology, University of Colorado School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10324-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.
