Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions

Yaquan Sun; Wei Jiang; Xiang Liao; Dongqing Wang; Dongqing Wang

doi:10.3389/fonc.2024.1421067

Frontiers in Oncology (Jul 2024)

Hallmarks of perineural invasion in pancreatic ductal adenocarcinoma: new biological dimensions

Yaquan Sun,
Wei Jiang,
Xiang Liao,
Dongqing Wang,
Dongqing Wang

Affiliations

Yaquan Sun: Institute of Medical Imaging and Artificial Intelligence, Jiangsu University, Zhenjiang, China
Wei Jiang: Institute of Medical Imaging and Artificial Intelligence, Jiangsu University, Zhenjiang, China
Xiang Liao: Institute of Medical Imaging and Artificial Intelligence, Jiangsu University, Zhenjiang, China
Dongqing Wang: Institute of Medical Imaging and Artificial Intelligence, Jiangsu University, Zhenjiang, China
Dongqing Wang: Department of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China

DOI: https://doi.org/10.3389/fonc.2024.1421067
Journal volume & issue: Vol. 14

Abstract

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Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor with a high metastatic potential. Perineural invasion (PNI) occurs in the early stages of PDAC with a high incidence rate and is directly associated with a poor prognosis. It involves close interaction among PDAC cells, nerves and the tumor microenvironment. In this review, we detailed discuss PNI-related pain, six specific steps of PNI, and treatment of PDAC with PNI and emphasize the importance of novel technologies for further investigation.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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